Bringing Sunlight to Light an Underground Garden

Imagine an inviting green park with tall, shady trees and wide swaths of grassy lawn where you can hear live music or see theater or simply sit quietly soaking up the noonday sun.
Now, imagine that all underground in an old disused parking garage … but still with trees and grass in the bright sunlight - a little less bright, of course, on cloudy days.
This paradoxical vision is already halfway to becoming a reality in downtown Manhattan, a dream made possible partly by fiber-optic technology that can capture sunlight on high rooftops and literally pipe it down to shine further from big underground "skylights."
Dan Barasch and James Ramsey envisioned it all in 2008 when they teamed up with an idea to transform an abandoned trolley terminal, a 1.5-acre lot underneath the Williamsburg Bridge and next to the Delancey St. subway station.
They dubbed their underground park the "Lowline," a nod to Manhattan's popular Highline Park that transformed another swatch of urban blight - in that case an unused and overgrown elevated rail bed.
PHOTOS: Lowline Park Project
Since they teamed up, Ramsey, an architect and principal at RAAD Studio, and Barasch, formerly VP of strategic partnerships for PopTech, have raised more than $500,000 for the project, including a Kickstarter campaign that totaled $155,000.
This past September, Ramsey and Barasch also staged an exhibit at a warehouse on Essex Street, just above where the proposed park would exist, in an effort to show the public what the Lowline could look like.
But lighting the underground space is a challenge and that is where Ramsey's background in engineering comes in; the former NASA employee turned architect had already been working on a way to collect and funnel light when he approached Barasch about the idea of an underground park.
Ramsey and Barasch explain their concept and in more detail here:
The technology consists of fiber optic cables attached to devices Ramsey refers to as remote skylights. Equipped with GPS, these solar collectors follow and capture the sun funneling it down through the cables. The glass surface of the skylights filters out infrared and UVA rays, but still harvests the light necessary for photosynthesis to take place.
For the exhibit, Ramsey and Barasch, alongside a team of volunteers put this technology to the test; together with their team they hand fit together 600 pieces of anodized-aluminum sheets to create a curved dome, a silver canopy that cast the light down on the warehouse space. On the warehouse roof, 20 feet above, six tracking systems collected the light and piped it down to the space below.
"We looked to the way that they build space telescopes to actually cobble together a mesh of flat pieces to create a very completed curved surface, and that curved surface is calibrated to actually deploy the light," said Ramsey, who worked with infrared spectrometry while at NASA.
With the help of volunteers, including engineers and team members from RAAD Studio, the duo created a mock-up complete with moss-covered knolls and Japanese maples. For their installation, they partnered with Sun Central, a Canadian-based solar technology firm, and Arup, a design and engineering firm that is also working on the Second Avenue subway line in Manhattan.
"All of a sudden you have this idea beginning to emerge where you can take this ancient disused space underneath the city and actually turn it into a public space, a garden really, for everyone to enjoy," Ramsey said.
Both Barasch and Ramsey point out despite their success so far, they still have a long way to go before making the Lowline a reality; first, they need to convince city and MTA officials (and ultimately the state) to let them use the site, a process that Barasch says requires both political and public support.
Barasch, who resigned from his position at PopTech in March, is devoting his efforts full time to the project focusing on fundraising and engaging with members of the community.
"This is not a short-term project," Barasch said. "It's very big in terms of its integration with the overall ecosystem of the space, the neighborhood, the subway line, the community and the city and we want to do this right."
If they gain control of the terminal, Ramsey and Barasch estimate the project would cost $50 million in capital costs for construction and may take five to eight years to complete. Nevertheless, both remain determined to see the Lowline complete.
"It taps into this thing that every human actually just needs, which is public space and some semblance of being outdoors as well as being inspired by making the city more beautiful, more livable," Barasch said.
For now, the trolley terminal remains an empty, shadowy cavern with an undetermined future, but one in which Ramsey and Barasch hope they can play a part.
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Cancer Immunotherapy Where Are We Going?

The compelling concept of utilizing the patient's own immune system for a stronger and more effective way to attack cancer cells is not a new one. William Coley observed in 1891 that infections produced in patients with inoperable cancer following an injection of streptococcal organisms (Gram-positive bacteria) led to tumor shrinkage especially when the patients developed fever and other signs of a full-blown infection.1 Since then, research has embraced approaches to "train" the patient's own immune system to recognize certain biomarkers or proteins that are mainly found on cancer cells and to destroy the cells.
After several setbacks the first cellular immunotherapy, Dendreon's Sipuleucel-T (Provenge(R)), was approved for the treatment of prostate cancer in 2010. Today, new promising cancer immunotherapy approaches are in clinical trials. Most recently, researchers at the 54th American Society of Hematology (ASH) meeting reported early success with a developmental-stage cell-based cancer vaccine for the treatment of leukemia and have shown remission in several patients 2,3, including a 7-year old girl who relapsed twice after chemotherapy.
Cancer immunotherapy can be thought of as either active or passive immunotherapy. The most prominent passive immunotherapies, which have revolutionized cancer therapy, are monoclonal antibodies that either target tumor-specific antigens and receptors or block important pathways central to tumor growth and survival. Therapeutic monoclonal antibodies are the market leader in the targeted cancer therapy space and include blockbusters such as trastuzumab (Herceptin(R)) or rituximab (Rituxan(R)).
In general, antibodies are significant elements of the body's adaptive immune system. They play a dominant role in the recognition of foreign antigens and the stimulation of the immune response. Therapeutic antibodies target and bind to antigens, usually proteins that are mainly expressed on diseased cells such as cancer cells. After binding, cancer cells can be destroyed by different mechanisms such as antibody-dependent cellular cytotoxicity, the activation of the complement system -- an important part of the immune system -- and triggering cell death.
Although very successful, especially in oncology, therapeutic antibodies have a significant limitation: they don't generate a memory response by the immune system, and thus, repeated antibody infusions are required. Further, monoclonal antibodies are only able to recognize specific proteins present of the cell surface. Monoclonal antibodies are mostly produced in cell culture systems which are often costly. Humanization of murine monoclonal antibodies by replacing of certain parts of the antibody with human sequences has improved the tolerability of antibodies and made them less immunogenic, but even fully human sequence-derived antibodies can carry some immunological risk.
Novel approaches in the passive immunization strategy include antibody drug conjugates, a combination of targeting antibody with a very potent drug such as the recently approved brentuximab vedotin (ADCETRIS(TM)) for Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL). ADCETRIS comprises an anti-CD30 monoclonal antibodyanti-CD30 monoclonal antibody and a cytotoxic (cell-killing) agent that is released upon internalization into CD30-expressing tumor cells. Currently, the development of next generations of ADCs is underway.
Alternatively, specific and durable cancer immunotherapies designed to actively "train" or stimulate the patient's intrinsic immune response have been more problematic; however, recent success stories, such as the cell-based immunotherapy Provenge, have revitalized this field. Dendreon's approach modifies the patients' own dendritic cells to present a protein specific to prostate cancer cells.
Dendritic cells are the most potent, "professional" antigen-presenting cells. They process the antigen material and present it on their surface to other cells of the immune system. Once activated, the dendritic cells migrate to the lymphoid tissues where they interact with T-cells and B-cells -- white blood cells and important components of the immune system -- to initiate and shape the adaptive immune response. To develop Provenge, each patient's own dendritic cells are harvested and then loaded ex vivo with the tumor-associated antigen. Now "presenting" the antigen, the dendritic cells are administered back into the patient to induce a potent, cell-mediated anticancer immune response resulting in tumor shrinkage and clinical benefit.
In another experimental approach for the treatment of leukemia, patients' own modified T-cells were infused back into the patients. Prior to this, the T-cells were transduced with a lentivirus to express the CD19-specific chimeric antigen receptor. CD19 is an antigen which is found on B-cell neoplasms, cancerous B-cells, and the lentivirus was the vehicle to transfer the genetic material for CD19 into the cells. A case report published in the New England Journal of Medicine stated that a patient with chronic lymphocytic leukemia (CLL) was in ongoing remission 10 months after treatment.3
These promising results have spurred continued research for new and safe ways to achieve effective tumor vaccination, and drug developers have explored many cancer immunotherapy strategies. To generate an effective antitumor immunity, therapeutic intervention should drive several functions; specifically, it should promote the antigen presentation functions of dendritic cells, promote the production of protective T-cell responses, stimulate B-cells and overcome immunosuppression characteristics that are common to tumor cells.4
Cell-based therapeutic vaccines are most frequently produced outside the patient's body and involve isolation of the specific cells, such as dendritic cells, and the introduction of preselected antigens, often with the use of specific vehicle, into the cells. The antigens can be encoded in viral vectors (frequently DNA) or administered as peptides or proteins in a suitable adjuvant and carrier through a long and cumbersome process.
During my doctoral thesis, I conducted immunization experiments using RNA as a negative control, assuming that the RNA would be degraded during the experiment thus making it impossible to use as a vaccine. The physiological role of messenger (m) RNA is to transfer genetic information from the nucleus to the cytoplasm where this information is translated into the corresponding protein. mRNA is known to be very unstable and has a relatively short half-life. But astonishingly, we were able to measure a solid T-cell immune response. We repeated the experiment and confirmed that the RNA we had produced had the potential to be used as a vaccine. Importantly, we didn't need to isolate the patients' cells: mRNA-based vaccines can be injected directly into the skin (intradermal). The mRNA-based vaccines are then taken up by antigen-presenting cells, such as dendritic cells, and are then able to induce an immune response. Importantly, mRNA-vaccines can also be synthesized quickly for any antigen sequence identified.5
The first mRNA-based vaccines (RNActive(R)) are now in the clinic for the treatment of prostate cancer and lung cancer and have demonstrated that they do what they are supposed to do - induce a balanced humoral, as well as T cell-mediated, immune response that is entirely HLA independent. The HLA (human leukocyte antigen) system is used to differentiate the body's own cells (self) and non-self cells. Additionally, RNA-vaccines do not need a vehicle such as a virus for delivery to the cells, nor do they contain virus-derived elements that are often found in DNA-vaccines. These attributes make RNActive a very safe therapeutic.
The risk of integration of the RNA into the host-genome is minimized (RNA would have been transcribed first to DNA, and then it has to be transported to the nucleus), as is the residual risk of DNA-based vaccines for inactivating or activating genes or affecting cellular regulatory elements, which can induce oncogenesis. Thus, the favorable safety profile of mRNA-based therapies broadens their potential use not only for the treatment of diseases but for use as prophylactic vaccinations. A recent proof-of-concept study using mRNA-based vaccines (RNActive) in animal models for influenza was published in Nature Biotechnology.6
Therapeutic cancer immunotherapies and vaccines have come a long way, and novel, promising approaches give hope for safe and effective treatment options. This may one day lead to the treatment of all cancers as chronic diseases.
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Viral Video Recap: Funniest Memes of the Week

A cat stuck in a box. A dramatic reading of Fifty Shades of Grey from George Takei. And another "Gangnam Style" remix. These are just three examples of the top videos that the web world watched this week.
We rounded up the most viral videos from this past week for your holiday weekend viewing pleasure. After all, what's better than explaining the significance of a philosophic cat to your mother at the dinner table?
[More from Mashable: 83 of 2012′s Best Viral Videos Crammed Into 4 Minutes]
What was your favorite video from this week? Tell us in the comments below.
12. Photobombing Stingray
Five years ago, three college girls on a Caribbean vacation got a serious case of the heebeejeebies when a stingray photobombed their “say cheese” moment. The hilarious photograph could have ended up as just a fond vacay memory if it weren’t for a friend, who shared the image on Reddit in September of this year.
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Top 5 Apps for Kids This Week

1. I Spy With Lola HD
Ages 3-8 Overall rating: 4.4 out of 5 stars Why we like it: This app effectively takes the common hunt-and-find play pattern down a notch by way of a series of carefully leveled challenges, clear labels and a playful theme. Need to know: Don't confuse this with the Scholastic I SPY titles. This is a different kettle of fish. And get the paid version. It is well worth the $2 -- there are no gimmicks or in-app purchases. Ease of use: 9/10 Educational: 9/10 Entertaining: 9/10 $1.99
Click here to view this gallery.
[More from Mashable: 10 Apps to Keep You Safe and Healthy in 2013]
Chris Crowell is a veteran kindergarten teacher and contributing editor to Children's Technology Review, a web-based archive of articles and reviews on apps, technology toys and video games. Download a free issue of CTR here.
In this week's Top 5 Kids Apps, we've got a creepy crawly feeling. Your kids can learn counting with Bugs and Numbers or take up Spanish as a hobby. There's also a beautifully-designed interactive e-book sure to capture your child's attention and spark the imagination.
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Analysis: Amazon, Google on collision course in 2013

When Amazon.com Inc CEO Jeff Bezos got word of a project at Google Inc to scan and digitize product catalogs a decade ago, the seeds of a burgeoning rivalry were planted.
The news was a "wake-up" call to Bezos, an early investor in Google. He saw it as a warning that the Web search engine could encroach upon his online retail empire, according to a former Amazon executive.
"He realized that scanning catalogs was interesting for Google, but the real win for Google would be to get all the books scanned and digitized" and then sell electronic editions, the former executive said.
Thus began a rivalry that will escalate in 2013 as the two companies' areas of rivalry grow, spanning online advertising and retail to mobile gadgets and cloud computing.
It could upend the last remaining areas of cooperation between the two companies. For instance, Amazon's decision to use a stripped down version of Google's Android system in its new Kindle Fire tablet, coupled with Google's ambitious plans for its Motorola mobile devices unit, will only add to tensions.
The confrontation marks the latest front in a tech industry war in which many combatants are crowding onto each others' turf. Lurking in the shadows for both Google and Amazon is Facebook with its own search and advertising ambitions.
"Amazon wants to be the one place where you buy everything. Google wants to be the one place where you find everything, of which buying things is a subset," said Chi-Hua Chien, a partner at venture capital firm Kleiner Perkins Caufield & Byers. "So when you marry those facts I think you're going to see a natural collision."
Both companies have a lot at stake. Google's market capitalization of $235 billion is about double Amazon's, largely because Google makes massive net earnings, expected by analysts to be $13.2 billion this year, based on a huge 32 percent net profit margin, according to Thomson Reuters I/B/E/S. By contrast, Amazon is seen reporting a small loss this year.
Amazon shareholders have been patient as the company has invested for growth but it will have to start producing strong earnings at some stage - more likely if it grows in higher margin areas such as advertising. Google's share price, on the other hand, is vulnerable to signs of slowing margin growth.
AD CLASH
Not long after Bezos learned of Google's catalog plans, Amazon began scanning books and providing searchable digital excerpts. Its Kindle e-reader, launched a few years later, owes much of its inspiration to the catalog news, the executive said.
Now, Amazon is pushing its online ad efforts, threatening to siphon revenue and users from Google's main search website.
Amazon's fledgling ad business is still a fraction of Google's, with Robert W. Baird & Co. estimating Amazon is on track to generate about $500 million in annual advertising revenue - tiny, given it recorded $48 billion of overall revenue in 2011. By contrast, 96 percent of Google's $38 billion in 2011 sales came from advertising.
But Amazon's newly developed "DSP" technology, which taps into the company's vast store of consumer purchase history to help marketers target ads at specific groups of people on Amazon.com and on other websites, could change all that.
"From a client's perspective, the data that Amazon owns is actually better than what Google has," said Mark Grether, the chief operating officer of Xaxis, an audience buying company that works with major advertisers. "They know what you just bought, and they also know what you are right now trying to buy."
Amazon is discussing a partnership with Xaxis in which the company would help Amazon sell ads for the service, Grether noted.
Amazon did not respond to an email seeking a comment.
STARTING POINT
Amazon can bring in higher-margin revenue by selling advertising than it can from its retail operations. By showing ads for products that it may not actually sell on its own website, Amazon establishes itself as a starting point for consumers looking to buy something on the Web.
Research firm Forrester reported that 30 percent of U.S. online shoppers in the third quarter began researching their purchase on Amazon.com, compared with 13 percent who started on a search engine such as Google - a reversal from two years earlier when search engines were more popular starting points.
Amazon now sells ads that show up to the side of product search results on its website. There were 6.7 billion display ad impressions on Amazon.com in the third quarter, more than triple the number in the same period of 2011, according to comScore.
That early success is a "huge concern" for Google, whose business relies heavily on product searches and product search ads, said Macquarie Research analyst Ben Schachter.
Partly in response, Google recently revamped its product search service, Google Shopping, by charging retailers and other online sellers a fee to be listed in results.
Founded four years apart in the late 1990s, Bezos has long worried about Amazon's reliance on Google for traffic, according to people close to the company, while also being dubious about Google's high market valuation.
"He'd say: ‘This is the first time in the history of the world where the map maker is worth more than the territory that it's mapping,'" recalled the former Amazon executive of Bezos' comments about Google's popular online mapping service.
TENSIONS BUILD
Google's Android system is thriving but still has not cracked the nut of how to make money from mobile search ads and sales of digital goods like games, apps, music and video.
"If they can figure out mobile ads, that would truly be Google's second act," said Forrester analyst Sucharita Mulpuru.
But Amazon launched a broadside against Google in 2011 with the creation of its own version of Android for its Kindle Fire tablets that replaces key Google money-making services, such as a digital music and application storefront, with its own.
Not unlike Apple, "Amazon wants to control the experience on their devices," said Oren Etzioni, a University of Washington computer science professor. "That doesn't make Google happy."
The two are also clashing in cloud computing software.
Amazon started its cloud business more than six years ago, providing data storage, computing power and other technology services from remote locations. Google only launched its cloud computing business this year, but the market is growing so quickly there is still room to grab share, Etzioni said.
"I would not write Google off," he added. "Amazon has the early lead but it's very early."
TRANSACT OR DIE?
Still, mobile gadgets and cloud computing are currently tiny businesses compared with the multibillion-dollar opportunity presented by advertising and online commerce.
Google recently acquired BufferBox, a company with a network of lockers that shoppers can use to receive packages. It is also testing same-day delivery in San Francisco, hinting at growing interest in a larger role in online retail.
It is not talking about its full plans for retail, but some analysts think features such as same-day delivery or "pick-up" lockers, are valuable features it can use to enhance its existing online ad business. An ad for shoes, for example, might also make the shoes available for pick-up in a locker nearby, said Needham & Co analyst Kerry Rice.
If Google can own the search and the delivery, it will be able to provide the same experience as Amazon, with no inventory - "a higher margin, more efficient model," Chien said.
Earlier this year, Google launched a new certification service highlighting merchants that ship quickly and reliably and backing it with up to $1,000 in "purchase protection."
Google could create a database of products and send shoppers to a page that has a way to buy quickly through the company's payments service Google Wallet, Forrester's Mulpuru said.
Google could then send that transaction to the retailer who would ship the product to the consumer. That ability is critical, according to Schachter, who said if consumers lack the ability to purchase items through Google it will lag Amazon and eBay Inc.
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Madonna leads Billboard's top-grossing tours

While this year's pop charts have been dominated by young singers, it is veteran music stars, led by Madonna, who are commanding big money in tour ticket sales, according to a new Billboard list released on Tuesday.
Madonna, 54, topped Billboard's list of highest-grossing live tours, earning an estimated $228.4 million in ticket sales from her sold-out ninth worldwide tour in support of her 12th studio album "MDNA." The singer will wrap her tour in South America this weekend, after performing more than 80 shows across the world starting in Israel in May.
Madonna came ahead of pop star Lady Gaga, who landed at No. 6, with ticket sales of $124.9 million from her worldwide "Born This Way Ball" tour. Gaga, 26, is currently midway through her tour, which kicked off in South Korea in April, and will wrap in Oklahoma in March 2013.
Music publication Billboard compiled its list through estimated gross ticket sales figures from Billboard box scores, which tracks concert tours, ticket prices and sales.
The top five highest-grossing tour acts of 2012 included Bruce Springsteen, 63, and the E Street band at No. 2 with $199 million from 72 shows and Pink Floyd's Roger Waters, 69, at No. 3 with $186 million.
Cirque Du Soleil's homage to late singer Michael Jackson in "The Immortal World Tour" ranked No. 4 with $147.3 million over 183 shows, and British rock band Coldplay was fifth with $147.2 million over 67 shows.
The only other young stars in the list of 25 top-grossing tours was Canadian pop star Justin Bieber, 18, at No. 20 with $30 million from 29 shows as part of his ongoing "Believe" tour, and country-pop darling Taylor Swift, 23, who raked in $26 million from 21 shows from her "Speak Now World Tour."
Last year, Swift ranked No. 5 on Billboard's list with an estimated $97 million in ticket sales from her "Speak Now World Tour," while Bieber came in at No. 15 with $44 million.
Swift will embark on her third worldwide concert tour in support of her studio album "Red" in March 2013.
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Taylor Swift keeps Bruno Mars out of Billboard 200 top spot

 Country pop star Taylor Swift held her reign at the top of the Billboard 200 album chart on Wednesday, keeping retro-inspired R&B singer Bruno Mars' new album at bay.
Swift's latest album, "Red," released in October, held the No. 1 slot for a fifth non-consecutive week with sales of 208,000, according to figures from Nielsen SoundScan.
Mars' second album, "Unorthodox Jukebox," sold 192,000 copies in its opening week to take the No. 2 slot.
The album's lead single, "Locked Out of Heaven," stayed at the top spot on the Billboard Hot 100 chart for a second week, and is the singer's fourth chart-topping single. It also tops the Digital Songs chart this week.
Hip hop artist The Game entered the chart at No. 6 with his fifth studio album, "Jesus Piece," selling 86,000 copies.
Four festive albums sat in the top ten this week, with Michael Buble's "Christmas" at No. 3, Rod Stewart's "Merry Christmas Baby" at No. 5, Blake Shelton's "Cheers, It's Christmas" at No. 8, and Lady Antebellum's "On This Winter's Night" at No. 10.
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Music, roses at singer Jenni Rivera's memorial

 Jenni Rivera's "celestial graduation" was marked by festive music, heartfelt speeches in Spanish and English and passionate chants of "Jen-ni! Jen-ni!"
Rivera's children and famed singers Olga Tanon and Joan Sebastian performed during the nearly 2 ½-hour Christian-themed memorial service Wednesday at the Gibson Amphitheatre, where thousands of fans gathered to salute the "Diva de la Banda" who died in a plane crash Dec. 9.
One fan, Veronika Flores, drove nearly eight hours from her home in Woodland, Calif., near Sacramento, to be united with other fans at the service.
"I just came to say goodbye to a Latina woman, La Gran Senora," she said, invoking the name of one of Rivera's most beloved songs.
Mexican singers Marco Antonio Solis and Ana Gabriel and actors Lou Diamond Phillips and Kate del Castillo were also among the guests at Wednesday's service.
A red casket sat onstage amid a sea of white roses as images of Rivera played on three big screens. Family members embraced and kissed the casket at the conclusion of the service, and thousands of fans lined up to lay more white roses atop it.
While most of the speeches and songs were delivered in Spanish, Rivera's children spoke in English, often directly to their late mother.
"We're not here to mourn the death," said son Michael, 21. "We're here to celebrate the life and graduation of a singer, an entertainer, a diva, a fighter, an entrepreneur, a philanthropist, and more than anything, a mother — the best mother."
He then called for 27 seconds of silence for the victims of the massacre in Newtown, Conn.
Rivera's youngest child, 11-year-old Johnny, was heartbreakingly poised as he said, "The person that everyone's talking about is my mom."
"Mama, I've been crying so much these last few days. I miss you so much," said the little boy, wearing a red bow tie like many of his family members. "I hope you're taking care of my dad and I hope he's taking care of you, too."
Rivera's second husband, Juan Lopez, died in 2009. The couple divorced in 2003.
Rivera's brothers and sisters spoke lovingly of the singer, calling her "the queen of queens," ''perfectly imperfect" and an "eternal diva." Her father said Rivera's "happiness, smile and care for the public will never be forgotten." He then performed a song he wrote about his daughter, a woman who rose from humble roots to become "la Diva de la Banda."
One of Rivera's brothers said his sister "made it OK for women to be who they are. Jenni also made it OK to be from nothing with the hopes of being something."
The family asked that Latin radio stations play Rivera's song "La Gran Senora" at noon Thursday in her honor.
The service was closed to most media, although a broadcast of the proceedings was made available. A reporter from The Associated Press obtained entry to the venue.
The burial will be private.
Rivera's last album before her death, "La Misma Gran Senora," topped the Latin albums chart this week, selling 27,000 copies — the best sales week for any Latin album this year. Rivera also holds three spots on the Billboard 200 albums chart.
Rivera and six other people died Dec. 9 in a northern Mexico plane crash that remains under investigation. Rivera, a mother of five children and grandmother of two, was 43.
Rivera sold more than 15 million copies of her 12 major-label albums. Her soulful singing style and honesty about her tumultuous personal life won her fans on both sides of the U.S.-Mexico border. She was also an actress and reality TV star.
Born in Los Angeles, Rivera launched her career by selling cassette tapes at flea markets. By the end of the 90s, she won a major-label contract and built a loyal following.
Many of her songs deal with themes of dignity in the face of heartbreak, which Rivera spoke of openly with her fans.
She had recently filed for divorce from her third husband, was once detained at a Mexico City airport with tens of thousands of dollars in cash, and publicly apologized after her brother assaulted a drunken fan who verbally attacked her in 2011.
"She was a fighter, a woman who can push boundaries," said Flores. "That's why I liked her, because I'm just like her.
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Singer Odell first male to win Brit newcomer award

 Singer-songwriter Tom Odell was named the Brit Awards' tip for the top in 2013, the first male artist to receive the honor previously won by chart queens including Adele and Jessie J.
The 22-year-old, whose musical style and voice has drawn comparisons to Coldplay lead singer Chris Martin, beat London electronic duo AlunaGeorge and classically trained soul singer Laura Mvula to the Critics' Choice Award.
Selected by a panel of music industry experts, the annual prize goes to a British artist tipped for mainstream success, and previous winners have gone on to top charts in Britain and beyond.
"Looking at the list of amazing female artists who have won the Award already, I just hope I don't let the boys down!" Odell said in a statement.
He released his debut E.P. "Songs From Another Love" in late 2012 and followed up with a performance on the popular live music show "Later...with Jools Holland".
Odell also appears on the BBC's Sound of 2013 longlist and MTV's Brand New For 2013 selection of 10 up-and-coming artists, as the music business seeks to identify the chart-toppers of tomorrow.
Many acts, including Odell, already have record deals with major labels.
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"Gangnam Style" in line for UK dictionary inclusion

He has the most-watched video in Youtube history, become a pop sensation with a horse-riding dance craze that has swept the world and now Korean singer Psy may cement his place in popular culture with recognition from a British dictionary.
"Gangnam Style," Psy's signature song, has been chosen along with "fiscal cliff" and "Romneyshambles" as some of Collins Dictionary's words of the year.
"We were looking for words that told the story of the year," said Ian Brookes, the dictionary's consultant editor.
"Some words are from events that have been and gone and so are not likely to stick around ... but others are probably here to stay."
Other headline entries centered on American politics.
"Fiscal cliff" has drawn a lot of attention as the deadline for Congress and President Obama to agree on government spending and tax plans draws nearer.
While the term "Romneyshambles" entered the British public's consciousness after Mitt Romney's gaffe-ridden visit to London in July in which he questioned Britain's readiness to host the Olympics.
The inclusion of "47 percent" on the list after a leaked video showed Romney telling donors that 47 percent of Americans would definitely vote for Obama because of their dependency on the government capped off a bad year for the losing presidential candidate.
Collins received over 7,000 submissions on its online database.
Twelve words of the year - one for each month - were then selected on the basis of the frequency with which they were spoken, how many places they appeared and their longevity in public discourse.
Appearing on the Collins words of the year list is no guarantee of insertion in the next dictionary.
But Gangnam Style stands a very good chance, Brookes said.
"It's obviously a craze, so there's the possibility it will go away. But it's been heard by so many people that I think it's probably earned the right to go into the dictionary."
Other words of the year include "mummy porn" after the popularity of the "Fifty Shades of Grey" books, and "superstorm" after Superstorm Sandy wreaked havoc along the east coast of America in October.
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